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  1. The identification of microbiota based on next-generation sequencing (NGS) of extracted DNA has drastically improved our understanding of the role of microbial communities in health and disease. However, DNA-b...

    Authors: Yacine Amar, Ilias Lagkouvardos, Rafaela L. Silva, Oluwaseun Ayodeji Ishola, Bärbel U. Foesel, Susanne Kublik, Anne Schöler, Sebastian Niedermeier, Rachela Bleuel, Alexander Zink, Klaus Neuhaus, Michael Schloter, Tilo Biedermann and Martin Köberle

    Citation: Microbiome 2021 9:123

    Content type: Research

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  2. Successful chemoprevention or chemotherapy is achieved through targeted delivery of prophylactic agents during initial phases of carcinogenesis or therapeutic agents to malignant tumors. Bacteria can be used a...

    Authors: Yusook Chung, Yongku Ryu, Byung Chull An, Yeo-Sang Yoon, Oksik Choi, Tai Yeub Kim, Jaekyung Yoon, Jun Young Ahn, Ho Jin Park, Soon-Kyeong Kwon, Jihyun F. Kim and Myung Jun Chung

    Citation: Microbiome 2021 9:122

    Content type: Research

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  3. The public transit is a built environment with high occupant density across the globe, and identifying factors shaping public transit air microbiomes will help design strategies to minimize the transmission of...

    Authors: M. H. Y. Leung, X. Tong, K. O. Bøifot, D. Bezdan, D. J. Butler, D. C. Danko, J. Gohli, D. C. Green, M. T. Hernandez, F. J. Kelly, S. Levy, G. Mason-Buck, M. Nieto-Caballero, D. Syndercombe-Court, K. Udekwu, B. G. Young…

    Citation: Microbiome 2021 9:112

    Content type: Research

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  4. Biogeochemical exports from watersheds are modulated by the activity of microorganisms that function over micron scales. Here, we tested the hypothesis that meander-bound regions share a core microbiome and ex...

    Authors: Paula B. Matheus Carnevali, Adi Lavy, Alex D. Thomas, Alexander Crits-Christoph, Spencer Diamond, Raphaël Méheust, Matthew R. Olm, Allison Sharrar, Shufei Lei, Wenming Dong, Nicola Falco, Nicholas Bouskill, Michelle E. Newcomer, Peter Nico, Haruko Wainwright, Dipankar Dwivedi…

    Citation: Microbiome 2021 9:121

    Content type: Research

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  5. In gut microbiome studies, the cultured gut microbial resource plays essential roles, such as helping to unravel gut microbial functions and host-microbe interactions. Although several major studies have been ...

    Authors: Chang Liu, Meng-Xuan Du, Rexiding Abuduaini, Hai-Ying Yu, Dan-Hua Li, Yu-Jing Wang, Nan Zhou, Min-Zhi Jiang, Peng-Xia Niu, Shan-Shan Han, Hong-He Chen, Wen-Yu Shi, Linhuan Wu, Yu-Hua Xin, Juncai Ma, Yuguang Zhou…

    Citation: Microbiome 2021 9:119

    Content type: Research

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  6. Beginning in the last century, coral reefs have suffered the consequences of anthropogenic activities, including oil contamination. Chemical remediation methods, such as dispersants, can cause substantial harm...

    Authors: Denise P. Silva, Helena D. M. Villela, Henrique F. Santos, Gustavo A. S. Duarte, José Roberto Ribeiro, Angela M. Ghizelini, Caren L. S. Vilela, Phillipe M. Rosado, Carolline S. Fazolato, Erika P. Santoro, Flavia L. Carmo, Dalton S. Ximenes, Adriana U. Soriano, Caio T. C. C. Rachid, Rebecca L. Vega Thurber and Raquel S. Peixoto

    Citation: Microbiome 2021 9:118

    Content type: Research

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  7. There is general consensus that consumption of dietary fermentable fiber improves cardiometabolic health, in part by promoting mutualistic microbes and by increasing production of beneficial metabolites in the...

    Authors: Sofia M. Murga-Garrido, Qilin Hong, Tzu-Wen L. Cross, Evan R. Hutchison, Jessica Han, Sydney P. Thomas, Eugenio I. Vivas, John Denu, Danilo G. Ceschin, Zheng-Zheng Tang and Federico E. Rey

    Citation: Microbiome 2021 9:117

    Content type: Research

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  8. The endoglycosidase heparanase which degrades heparan sulfate proteoglycans, exerts a pro-inflammatory mediator in various inflammatory disorders. However, the function and underlying mechanism of heparanase i...

    Authors: Yuanyuan Lei, Li Tang, Shuang Liu, Shiping Hu, Lingyi Wu, Yaojiang Liu, Min Yang, Shengjie Huang, Xuefeng Tang, Tao Tang, Xiaoyan Zhao, Israel Vlodavsky, Shuo Zeng, Bo Tang and Shiming Yang

    Citation: Microbiome 2021 9:115

    Content type: Research

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  9. Recent advances in metagenomic technology and computational prediction may inadvertently weaken an individual’s reasonable expectation of privacy. Through cross-kingdom genetic and metagenomic forensics, we ca...

    Authors: Eran Elhaik, Sofia Ahsanuddin, Jake M. Robinson, Emily M. Foster and Christopher E. Mason

    Citation: Microbiome 2021 9:114

    Content type: Commentary

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  10. Microbiome research has gained considerable interest due to the emerging evidence of its impact on human and animal health. As in other animals, the gut-associated microbiota of mosquitoes affect host fitness ...

    Authors: Cintia Cansado-Utrilla, Serena Y. Zhao, Philip J. McCall, Kerri L. Coon and Grant L. Hughes

    Citation: Microbiome 2021 9:111

    Content type: Review

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  11. Total DNA (intracellular, iDNA and extracellular, eDNA) from ancient permafrost records the mixed genetic repository of the past and present microbial populations through geological time. Given the exceptional...

    Authors: Renxing Liang, Zhou Li, Maggie C. Y. Lau Vetter, Tatiana A. Vishnivetskaya, Oksana G. Zanina, Karen G. Lloyd, Susan M. Pfiffner, Elizaveta M. Rivkina, Wei Wang, Jessica Wiggins, Jennifer Miller, Robert L. Hettich and Tullis C. Onstott

    Citation: Microbiome 2021 9:110

    Content type: Research

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  12. One of the most charismatic, and yet not completely resolved example of mutualistic interaction is the partnership of clownfish and its symbiotic sea anemone. The mechanism explaining this tolerance currently ...

    Authors: Audet-Gilbert Émie, Sylvain François-Étienne, Bouslama Sidki and Derome Nicolas

    Citation: Microbiome 2021 9:109

    Content type: Research

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  13. Soil is an important reservoir of antibiotic resistance genes (ARGs), but their potential risk in different ecosystems as well as response to anthropogenic land use change is unknown. We used a metagenomic app...

    Authors: Xun Qian, Santosh Gunturu, Jiarong Guo, Benli Chai, James R. Cole, Jie Gu and James M. Tiedje

    Citation: Microbiome 2021 9:108

    Content type: Research

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  14. Donor selection is an important factor influencing the engraftment and efficacy of fecal microbiota transplantation (FMT) for complex conditions associated with microbial dysbiosis. However, the degree, variat...

    Authors: Brooke C. Wilson, Tommi Vatanen, Thilini N. Jayasinghe, Karen S. W. Leong, José G. B. Derraik, Benjamin B. Albert, Valentina Chiavaroli, Darren M. Svirskis, Kathryn L. Beck, Cathryn A. Conlon, Yannan Jiang, William Schierding, David J. Holland, Wayne S. Cutfield and Justin M. O’Sullivan

    Citation: Microbiome 2021 9:107

    Content type: Research

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  15. The gut microbiome and iron status are known to play a role in the pathophysiology of non-alcoholic fatty liver disease (NAFLD), although their complex interaction remains unclear.

    Authors: Jordi Mayneris-Perxachs, Marina Cardellini, Lesley Hoyles, Jèssica Latorre, Francesca Davato, José Maria Moreno-Navarrete, María Arnoriaga-Rodríguez, Matteo Serino, James Abbott, Richard H. Barton, Josep Puig, Xavier Fernández-Real, Wifredo Ricart, Christopher Tomlinson, Mark Woodbridge, Paolo Gentileschi…

    Citation: Microbiome 2021 9:104

    Content type: Research

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  16. Plants influence their root and rhizosphere microbial communities through the secretion of root exudates. However, how specific classes of root exudate compounds impact the assembly of root-associated microbio...

    Authors: Selma Cadot, Hang Guan, Moritz Bigalke, Jean-Claude Walser, Georg Jander, Matthias Erb, Marcel G. A. van der Heijden and Klaus Schlaeppi

    Citation: Microbiome 2021 9:103

    Content type: Research

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  17. Microbiome manipulation could enhance heat tolerance and help corals survive the pressures of ocean warming. We conducted coral microbiome transplantation (CMT) experiments using the reef-building corals, Pocillo...

    Authors: Talisa Doering, Marlene Wall, Lalita Putchim, Tipwimon Rattanawongwan, Roman Schroeder, Ute Hentschel and Anna Roik

    Citation: Microbiome 2021 9:102

    Content type: Research

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  18. The characteristics of polycystic ovary syndrome (PCOS), a common reproductive endocrinal disorder, are high incidence, complicated aetiology and poor therapeutic effects. PCOS patients frequently exhibit gut ...

    Authors: Qixin Han, Juan Wang, Weiping Li, Zi-Jiang Chen and Yanzhi Du

    Citation: Microbiome 2021 9:101

    Content type: Research

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  19. The objective of this study was to increase understanding of the complex interactions between diet, obesity, and the gut microbiome of adult female non-human primates (NHPs). Subjects consumed either a Western (n

    Authors: Tiffany M. Newman, Carol A. Shively, Thomas C. Register, Susan E. Appt, Hariom Yadav, Rita R. Colwell, Brian Fanelli, Manoj Dadlani, Karlis Graubics, Uyen Thao Nguyen, Sivapriya Ramamoorthy, Beth Uberseder, Kenysha Y. J. Clear, Adam S. Wilson, Kimberly D. Reeves, Mark C. Chappell…

    Citation: Microbiome 2021 9:100

    Content type: Research

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  20. Low-biomass microbiome studies (such as those of the lungs, placenta, and skin) are vulnerable to contamination and sequencing stochasticity, which obscure legitimate microbial signal. While human lung microbi...

    Authors: Jennifer M. Baker, Kevin J. Hinkle, Roderick A. McDonald, Christopher A. Brown, Nicole R. Falkowski, Gary B. Huffnagle and Robert P. Dickson

    Citation: Microbiome 2021 9:99

    Content type: Research

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  21. RNA interference (RNAi) has emerged as an efficient tool to control insect pests. When insects ingest double-stranded RNAs (dsRNAs) targeted against essential genes, strong gene silencing and mortality can be ...

    Authors: Letian Xu, Shijing Xu, Liuwei Sun, Yiqiu Zhang, Jing Luo, Ralph Bock and Jiang Zhang

    Citation: Microbiome 2021 9:98

    Content type: Research

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  22. Although localized aggressive periodontitis (LAP), generalized aggressive periodontitis (GAP), and chronic periodontitis (CP) are microbially driven diseases, our inability to separate disease-specific associa...

    Authors: Khaled Altabtbaei, Pooja Maney, Sukirth M. Ganesan, Shareef M. Dabdoub, Haikady N. Nagaraja and Purnima S. Kumar

    Citation: Microbiome 2021 9:97

    Content type: Research

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  23. Validation and standardization of methodologies for microbial community measurements by high-throughput sequencing are needed to support human microbiome research and its industrialization. This study set out ...

    Authors: Dieter M. Tourlousse, Koji Narita, Takamasa Miura, Mitsuo Sakamoto, Akiko Ohashi, Keita Shiina, Masami Matsuda, Daisuke Miura, Mamiko Shimamura, Yoshifumi Ohyama, Atsushi Yamazoe, Yoshihito Uchino, Keishi Kameyama, Shingo Arioka, Jiro Kataoka, Takayoshi Hisada…

    Citation: Microbiome 2021 9:95

    Content type: Methodology

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  24. Despite their widespread distribution and ecological importance, protists remain one of the least understood components of the soil and rhizosphere microbiome. Knowledge of the roles that protists play in stim...

    Authors: Javier A. Ceja-Navarro, Yuan Wang, Daliang Ning, Abelardo Arellano, Leila Ramanculova, Mengting Maggie Yuan, Alyssa Byer, Kelly D. Craven, Malay C. Saha, Eoin L. Brodie, Jennifer Pett-Ridge and Mary K. Firestone

    Citation: Microbiome 2021 9:96

    Content type: Research

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  25. The gut microbiota–intestine–liver relationship is emerging as an important factor in multiple hepatic pathologies, but the hepatic sensors and effectors of microbial signals are not well defined.

    Authors: Sharon Ann Barretto, Frederic Lasserre, Marine Huillet, Marion Régnier, Arnaud Polizzi, Yannick Lippi, Anne Fougerat, Elodie Person, Sandrine Bruel, Colette Bétoulières, Claire Naylies, Céline Lukowicz, Sarra Smati, Laurence Guzylack, Maïwenn Olier, Vassilia Théodorou…

    Citation: Microbiome 2021 9:93

    Content type: Research

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  26. Infectious bacterial diseases exhibiting increasing resistance to antibiotics are a serious global health issue. Bacteriophage therapy is an anti-microbial alternative to treat patients with serious bacterial ...

    Authors: Andre Mu, Daniel McDonald, Alan K. Jarmusch, Cameron Martino, Caitriona Brennan, Mackenzie Bryant, Gregory C. Humphrey, Julia Toronczak, Tara Schwartz, Dominic Nguyen, Gail Ackermann, Anthony D’Onofrio, Steffanie A. Strathdee, Robert T. Schooley, Pieter C. Dorrestein, Rob Knight…

    Citation: Microbiome 2021 9:92

    Content type: Short report

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  27. Coronavirus disease 2019 (COVID-19) caused by the enveloped RNA virus SARS-CoV-2 primarily affects the respiratory and gastrointestinal tracts. SARS-CoV-2 was isolated from fecal samples, and active viral repl...

    Authors: Tao Zuo, Qin Liu, Fen Zhang, Yun Kit Yeoh, Yating Wan, Hui Zhan, Grace C. Y. Lui, Zigui Chen, Amy Y. L. Li, Chun Pan Cheung, Nan Chen, Wenqi Lv, Rita W. Y. Ng, Eugene Y. K. Tso, Kitty S. C. Fung, Veronica Chan…

    Citation: Microbiome 2021 9:91

    Content type: Research

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  28. The objective of this project was to increase the sensitivity of sequence-based bacterial community determination without impacting community composition or interfering with cluster formation during sequencing...

    Authors: Kayla M. Williamson, Brandie D. Wagner, Charles E. Robertson, Mark J. Stevens, Marci K. Sontag, Peter M. Mourani and J. Kirk Harris

    Citation: Microbiome 2021 9:90

    Content type: Research

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  29. The gut phageome comprises a complex phage community of thousands of individual strains, with a few highly abundant bacteriophages. CrAss-like phages, which infect bacteria of the order Bacteroidales, are the ...

    Authors: Emma Guerin, Andrey N. Shkoporov, Stephen R. Stockdale, Joan Colom Comas, Ekaterina V. Khokhlova, Adam G. Clooney, Karen M. Daly, Lorraine A. Draper, Niamh Stephens, Dimitri Scholz, R. Paul Ross and Colin Hill

    Citation: Microbiome 2021 9:89

    Content type: Research

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  30. Acute hepatopancreatic necrosis disease (AHPND) is an important shrimp bacterial disease caused by some Vibrio species. The severity of the impact of this disease on aquaculture worldwide has made it necessary to...

    Authors: Leda Restrepo, Cristóbal Domínguez-Borbor, Leandro Bajaña, Irma Betancourt, Jenny Rodríguez, Bonny Bayot and Alejandro Reyes

    Citation: Microbiome 2021 9:88

    Content type: Research

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  31. Free-living and symbiotic chemosynthetic microbial communities support primary production and higher trophic levels in deep-sea hydrothermal vents. The shrimp Rimicaris exoculata, which dominates animal communiti...

    Authors: Marie-Anne Cambon-Bonavita, Johanne Aubé, Valérie Cueff-Gauchard and Julie Reveillaud

    Citation: Microbiome 2021 9:87

    Content type: Research

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  32. Microbes benefit plants by increasing nutrient availability, producing plant growth hormones, and protecting against pathogens. However, it is largely unknown how plants change root microbial communities.

    Authors: Chuntao Yin, Juan M. Casa Vargas, Daniel C. Schlatter, Christina H. Hagerty, Scot H. Hulbert and Timothy C. Paulitz

    Citation: Microbiome 2021 9:86

    Content type: Research

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  33. Microbial-driven decomposition of plant residues is integral to carbon sequestration in terrestrial ecosystems. Actinobacteria, one of the most widely distributed bacterial phyla in soils, are known for their abi...

    Authors: Yuanyuan Bao, Jan Dolfing, Zhiying Guo, Ruirui Chen, Meng Wu, Zhongpei Li, Xiangui Lin and Youzhi Feng

    Citation: Microbiome 2021 9:84

    Content type: Research

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  34. Ulcerative colitis is a type of chronic inflammatory bowel disease closely associated with gut microbiota dysbiosis and intestinal homeostasis dysregulation. Barley leaf (BL) has a long history of use in Tradi...

    Authors: Daotong Li, Yu Feng, Meiling Tian, Junfu Ji, Xiaosong Hu and Fang Chen

    Citation: Microbiome 2021 9:83

    Content type: Research

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  35. Clean rooms of the Space Assembly Facility (SAF) at the Jet Propulsion Laboratory (JPL) at NASA are the final step of spacecraft cleaning and assembly before launching into space. Clean rooms have stringent me...

    Authors: David C. Danko, Maria A. Sierra, James N. Benardini, Lisa Guan, Jason M. Wood, Nitin Singh, Arman Seuylemezian, Daniel J. Butler, Krista Ryon, Katerina Kuchin, Dmitry Meleshko, Chandrima Bhattacharya, Kasthuri J. Venkateswaran and Christopher E. Mason

    Citation: Microbiome 2021 9:82

    Content type: Research

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  36. Research is needed to delineate the relative and combined effects of different antibiotic administration and manure management practices in either amplifying or attenuating the potential for antibiotic resista...

    Authors: Ishi Keenum, Robert K. Williams, Partha Ray, Emily D. Garner, Katharine F. Knowlton and Amy Pruden

    Citation: Microbiome 2021 9:81

    Content type: Research

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  37. Double-stranded DNA bacteriophages (dsDNA phages) play pivotal roles in structuring human gut microbiomes; yet, the gut virome is far from being fully characterized, and additional groups of phages, including ...

    Authors: Sean Benler, Natalya Yutin, Dmitry Antipov, Mikhail Rayko, Sergey Shmakov, Ayal B. Gussow, Pavel Pevzner and Eugene V. Koonin

    Citation: Microbiome 2021 9:78

    Content type: Research

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  38. Temperate phages influence the density, diversity and function of bacterial populations. Historically, they have been described as carriers of toxins. More recently, they have also been recognised as direct mo...

    Authors: Mirjam Zünd, Hans-Joachim Ruscheweyh, Christopher M. Field, Natalie Meyer, Miguelangel Cuenca, Daniel Hoces, Wolf-Dietrich Hardt and Shinichi Sunagawa

    Citation: Microbiome 2021 9:77

    Content type: Research

    Published on:

  39. Microbial communities that live in and on the human body play a vital role in health and disease. Recent advances in sequencing technologies have enabled the study of microbial communities at unprecedented res...

    Authors: Yue Zhao, Anthony Federico, Tyler Faits, Solaiappan Manimaran, Daniel Segrè, Stefano Monti and W. Evan Johnson

    Citation: Microbiome 2021 9:76

    Content type: Software article

    Published on:

  40. Recent studies suggested the existence of (poly-)microbial infections in human brains. These have been described either as putative pathogens linked to the neuro-inflammatory changes seen in Parkinson’s diseas...

    Authors: Janis R. Bedarf, Naiara Beraza, Hassan Khazneh, Ezgi Özkurt, David Baker, Valeri Borger, Ullrich Wüllner and Falk Hildebrand

    Citation: Microbiome 2021 9:75

    Content type: Research

    Published on:

  41. While several studies have documented associations between dietary habits and microbiota composition and function in healthy individuals, no study explored these associations in patients with irritable bowel s...

    Authors: Julien Tap, Stine Störsrud, Boris Le Nevé, Aurélie Cotillard, Nicolas Pons, Joël Doré, Lena Öhman, Hans Törnblom, Muriel Derrien and Magnus Simrén

    Citation: Microbiome 2021 9:74

    Content type: Research

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